Neuropeptide Y—Mediated Constriction and Dilation in Rat Middle Cerebral Arteries
نویسندگان
چکیده
منابع مشابه
Interaction of myogenic mechanisms and hypoxic dilation in rat middle cerebral arteries.
The goal of this study was to determine how myogenic responses and vascular responses to reduced Po(2) interact to determine vascular smooth muscle (VSM) transmembrane potential and active tone in isolated middle cerebral arteries from Sprague-Dawley rats. Stepwise elevation of transmural pressure led to depolarization of the VSM cells and myogenic constriction, and reduction of the O(2) concen...
متن کاملKv2 channels oppose myogenic constriction of rat cerebral arteries.
By hyperpolarizing arterial smooth muscle, voltage-gated, Ca2+-independent K+ (Kv) channels decrease calcium influx and thus oppose constriction. However, the molecular nature of the Kv channels function in arterial smooth muscle remains controversial. Recent investigations have emphasized a predominant role of Kv1 channels in regulating arterial tone. In this study, we tested the hypothesis Kv...
متن کاملBiaxial and failure properties of passive rat middle cerebral arteries.
Rodents are commonly used as test subjects in research on traumatic brain injury and stroke. However, study of rat cerebral vessel properties has largely been limited to pressure-diameter response within the physiological loading range. A more complete, multiaxial description is needed to guide experiments on rats and rat vessels and to appropriately translate findings to humans. Accordingly, w...
متن کاملImpaired pressure-induced constriction in mouse middle cerebral arteries of ASIC2 knockout mice.
Recent studies from our laboratory demonstrated the importance of mechanosensitive epithelial Na(+) channel (ENaC) proteins in pressure-induced constriction in renal and cerebral arteries. ENaC proteins are closely related to acid-sensing ion channel 2 (ASIC2), a protein known to be required for normal mechanotransduction in certain sensory neurons. However, the role of the ASIC2 protein in pre...
متن کاملCoactivation of NMDA receptors by glutamate and D-serine induces dilation of isolated middle cerebral arteries.
N-methyl-D-aspartate (NMDA) receptors are glutamate-gated cation channels that mediate excitatory neurotransmission in the central nervous system. In addition to glutamate, NMDA receptors are also activated by coagonist binding of the gliotransmitter, D-serine. Neuronal NMDA receptors mediate activity-dependent blood flow regulation in the brain. Our objective was to determine whether NMDA rece...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Journal of Cerebral Blood Flow & Metabolism
سال: 2001
ISSN: 0271-678X,1559-7016
DOI: 10.1097/00004647-200101000-00010